Peripheral artery disease

Peripheral artery disease is a disease of the limbs (legs predominantly) which features progressive or acute occlusion through arteriosclerotic plaque or the embolisms that detach from it. The occlusion can originate from inflammatory processes, for example through thromboangiitis obliterans.

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The symptoms appear in relation to increased oxygen requirement, during physical exercise for example, when the limb with the occlusion has a greater demand. The ischaemia that arises causes accumulation of toxic substances in the affected tissue which can cause pain. The pain occurs first of all during movement. Usually the pain attenuates with rest. In this situation it takes the name intermittent claudication because of the typical progress of the symptoms in the classical form, which forces the patient to stop because of cramps, after having walked variable distances (from 50 to 200 m depending on severity). In the more advanced stages of the disease the patient is forced to hold their legs over the side of the bed almost continually to increase blood flow, promoting oxygen to reduce the ischaemia and the now continual pain, even at rest.

Why Zentrum

The vasodilatory capacities of the L-Arginine contained in Zentrum and its endothelial functions support the body in tackling the problems associated with this disease. The use of Zentrum, associated with a good and healthy diet, can help the body to increase pain-free physical exercise.

Before undergoing treatment it is always appropriate to consult a specialist, so that together you can decide on the timescales and methods.


The use of arginine is contraindicated for persons who frequently experience outbreaks of herpes virus. The L-arginine amino acid can reactivate episodes of that strain of virus.